24 research outputs found
Targeting the Mechanisms of Resistance to Chemotherapy and Radiotherapy with the Cancer Stem Cell Hypothesis
Despite advances in treatment, cancer remains the 2nd most common cause of death in the United States. Poor cure rates may result from the ability of cancer to recur and spread after initial therapies have seemingly eliminated detectable signs of disease. A growing body of evidence supports a role for cancer stem cells (CSCs) in tumor regrowth and spread after initial treatment. Thus, targeting CSCs in combination with traditional induction therapies may improve treatment outcomes and survival rates. Unfortunately, CSCs tend to be resistant to chemo- and radiation therapy, and a better understanding of the mechanisms underlying CSC resistance to treatment is necessary. This paper provides an update on evidence that supports a fundamental role for CSCs in cancer progression, summarizes potential mechanisms of CSC resistance to treatment, and discusses classes of drugs currently in preclinical or clinical testing that show promise at targeting CSCs
Switch between apoptosis and autophagy: Radiation-induced endoplasmic reticulum stress?
info:eu-repo/semantics/publishe
SU‐GG‐I‐99: Registration and Active Shape ModelâBased Segmentation of Lymph Node Regions in Head and Neck CT Images
info:eu-repo/semantics/publishe
MO‐D‐204B‐06: Segmentation Evaluation in the Context of Inter-Physician Variance
info:eu-repo/semantics/publishe
Enzastaurin (LY317615), a protein kinase C beta selective inhibitor, enhances antiangiogenic effect of radiation
info:eu-repo/semantics/publishe
MLN8054, a small molecule inhibitor of aurora kinase a, sensitizes androgen-resistant prostate cancer to radiation.
To determine whether MLN8054, an Aurora kinase A (Aurora-A) inhibitor causes radiosensitization in androgen-insensitive prostate cancer cells in vitro and in vivo.Journal ArticleResearch Support, U.S. Gov't, Non-P.H.S.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Enhanced radiosensitivity of androgen-resistant prostate cancer: AZD1152-mediated aurora kinase B inhibition
info:eu-repo/semantics/publishe